云南香格里拉高獐牙菜的化学成分研究
A study of the chemical constituents in Swertia elata in Yunnan
云南民族大学学报:自然科学版,2017,26(4):265-270

阚雪清 KXQ

摘要


对采自云南省香格里拉县海拔4000m的龙胆科( Gentianaceae )獐牙菜属植物高獐牙菜(Swertia elata)的化学成分进行研究.方法采用正相硅胶柱色谱,Sephadex LH-20凝胶柱色谱,HPLC,Zorbax Prep HT GF反相柱色谱及MCI等现代分离分析技术进行分离和纯化,并用95%的乙醇对该植物全株进行超声提取,在其正丁醇萃取部分分离出10个已知的化合物.并根据理化性质和波谱数据鉴定化合物结构分别为:1-羟基-3,5,8-三甲氧基酮(1), 1-羟基-3,5-二甲氧基酮(2),1,7-二羟基-3,8-二甲氧基酮(3), 1-羟基-3,7,8-三甲氧基酮(4),1,5-二羟基-3,8-二甲氧基酮(5),1,8-二羟基-3,7-二甲氧基酮(6),1,3-二羟基-7,8-二甲氧基酮(7),獐牙菜苷(8),(E)-aldosecologanin(9),葡萄糖香草醛苷(10),其中化合物9为首次从獐牙菜属植物中提取分离得到.This was a study of the chemical constituents of Swertia elata in Shangri-la in Yunnan province and ten compounds were obtained. Compounds 1-10 were isolated and purified by modern separation technologies like silica gel column-chromatography, Sephadex LH-20 gel column chromatography, HPLC, Zorbax PrepHT GF (250mm×21.2mm) reversed phase and MCI. According to the spectroscopic analysis and comparison with the data reported in the literature, their structures were characterized as follows: 1-hydroxy-3, 5, 8-trimethoxy-xanthen-9-one(1), 1-hydroxy-3, 5-dimethoxy-xanthen-9-one(2), 1,7-dihydroxy-3, 8-dimethoxy-xanthen-9-one(3), 1-hydroxy-3, 7, 8- trimethoxy - xanthen-9-one(4), 1, 5-dihydroxy-3, 8-dimethoxy-xanthen-9-one(5), 1, 8-dihydroxy-3, 7-dimethoxy-xanthen-9-one(6), 1,3-dihydroxy-7, 8-dimethoxy-xanthen-9-one(7), sweroside(8), (E)-aldosecologanin(9), vanilloloside(10), of which (9) was isolated from Swertia genus for the first time.

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