长春胺/β-环糊精衍生物包合物的制备及水溶性研究
A study of the preparation and water solubility of the inclusion compounds of Vincamine with β-cyclodextrin derivatives
云南民族大学学报:自然科学版,2017,26(3):179-184

王淑慧 WSH

摘要


采用紫外-可见光谱滴定法,分别测定了主体分子β-环糊精及其衍生物 (DMβCD和TMβCD) 与客体分子长春胺药物在pH=3.0和pH=10.5的缓冲溶液中形成配位包合物时的稳定常数(Ks),通过X线粉末衍射和差热分析对其包合物进行表征.结果表明:长春胺与环糊精(β-CD,DMβCD和TMβCD)形成包合时,β-CD的稳定常数(Ks)相对较高.主客体形成包合物能显著地提高长春胺的水溶性. Ultraviolet-visible spectroscopic titrations were performed in the aqueous buffer solution (pH=3.0, pH =10.5) at 25℃ to determine the binding constants of β-CD and its derivatives (DMβCD and TMβCD) with Vincamine guest molecules. Then inclusion complexes of Vincamine with β-cyclodextrin derivatives have been studied by using FT-IR analysis, X-ray power diffraction and thermal gravimetric analysis. The results indicate that the stability constant of β-CD is relatively high in the inclusion complex of Vincamine with β-cyclodextrin derivatives. After the formation of host-guest inclusion complex structure can significantly improve the water solubility of vincamine.

参考



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