东革阿里树皮的化学成分研究
Chemical constituents of the barks of Eurycoma longifolia growing in Thailand
Chemical constituents of the barks of Eurycoma longifolia growing in Thailand

杨美莲 YML

摘要


利用溶剂提取和正、反相色谱法、Sephadex LH-20凝胶柱色谱等技术对泰国产东革阿里(Eurycoma longifolia)树皮的化学成分进行分离纯化.采用核磁共振、质谱等波谱技术鉴定化合物的结构.从泰国产东革阿里树皮提取物中分离得到8个化合物,分别鉴定为铁屎米酮(1),铁屎米酮-N(3)-氧化物(2),9-羟基铁屎米酮(3),9-甲氧基铁屎米酮(4),9,10-二甲氧基铁屎米酮(5),东哥内酯 (6),宽缨酮(7),豆甾-4,22-二烯-3-酮(8).化合物1~5为β-咔巴啉类生物碱,化合物6~7为苦木萜类成分,化合物8为甾体化合物,除化合物5和6外,其他6个化合物均为首次从该植物树皮中分离得到. This paper studied the chemical constituents of the barks of Eurycoma longifolia growing in Thailand. The compounds were isolated and purified by various kinds of column chromatography, such as the silica gel column, MPLC, semi-preparative HPLC, and Sephadex LH-20. The structures were elucidated by NMR spectroscopic methods in combination with MS experiments. The results showed that eight compounds were isolated from Eurycoma longifolia, and identified as canthin-6-one (1), canthin-6-one-N(3)-Oxide (2), 9-hydroxycanthin-6-one (3), 9-methoxycanthin-6-one (4), 9,10-dimethoxycanthin-6-one (5), eurycomalactone (6), eurycomanone (7), and stigmast-4,22-dien-3-one (8). It concluded that compounds 1—5 were β-carbolin alkaloids, 6—7 were quassinoids, while 8 was a steroid, of which compounds 1—4 and 7—8 were isolated from the barks of this plant for the first time.

参考



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