14-去甲基自溶霉素C11~C15片段的合成研究
Synthesis of the C11—C15 fragment of 14-demethylautolymycin
云南民族大学学报:自然科学版,2014,23(3):167-171

冯亮 FL

摘要


研究了14-去甲基自溶霉素C11~C15片段的合成.自溶霉素及类似物具有较好的抗癌活性,其全合成引起了广泛关注.以L-谷氨酸为手性原料,经8步完成了14-去甲基自溶霉素C11~C15片段的合成.其中,应用了NaBH4/BF3·Et2O还原羧酸,以及质子海绵/Me3OBF4实现邻硅氧基醇甲基化的方法. A synthesis of the C11—C15 fragment of 14-demethylautolytimycin was developed. The total synthesis of autolytimycin and its analogs has attracted significant attention because of their promising anticancer profiles. Started from L-glutamic acid, the C11—C15 fragment was synthesized in 8 steps, using a NaBH4/BF3·Et2O combination for carboxyl reduction and a proton sponge/Me3OBF4 combination for 2-siloxyl alcohol methylation.

参考



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